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Israeli scientists successfully regenerate damaged hearts
Life in Israel
Israeli scientists successfully regenerate damaged hearts

Israeli scientists have isolated a molecule that promotes heart cell regeneration, according to the results of a new study published in Nature magazine, a discovery that could offer hope to millions of sufferers of cardiovascular diseases around the world. 

The study, led by Rehovot’s Weizmann Institute of Science in cooperation with several other schools in Israel and in the US, examined the effect of an embryonic protein on adult heart regeneration.

While heart regeneration in mammals has been observed during the prenatal stage, it is virtually impossible for the blood-pumping organ to heal after birth. Any damage to the heart from that point on, through heart attacks or other maladies, is there to stay.

Even worse, the healthy heart muscle cells, or cardiomyocytes, are replaced by scar tissue that places further burden on the remaining healthy cells.

Thus, any damage to the heart only increases the risk of further degeneration and eventual failure.

Researchers studied a protein called Agrin, common in fetal hearts, which rapidly disappears after birth. They now believe Agrin, which resides in the space between prenatal heart cells, controls the process of cardiomyocyte regeneration.

The scientists extracted Agrin from the hearts of newborn mice, which retain the protein for about a week after birth, and tested it in various environments, to highly encouraging results.

The team has now begun pre-clinical studies on larger animals in Germany, in cooperation with the Technical University of Munich.

The World Health Organisation says heart disease is the top cause of death globally. In 2015, an estimated 17.7 million people died from cardiovascular ailments — 31 per cent of total worldwide deaths.

 Click here to read the full article in Times of Israel

Thursday, June 22, 2017
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